ceesdekker No Further a Mystery
Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy methods, we seek out to unravel the mechanistic aspects of the construction and dynamics of chromosomes. Our investigation passions incorporate:1996, very first mesoscopic demand density waves devices; and 1st electrical measurements on only one metal nanocluster amongst nanoelectrodes
[Laughs] ‘It was definitely a great risk! At some time, I had been very well mindful that it could go Mistaken and that I could turn out to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortunately it all worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
That may be a dream of mine and we established to operate having a delightful dose of naivety. This really is something which will most likely yield stunning brings about the lengthier expression, but that doesn't matter. You should not only want to work to the questions of tomorrow, but in addition to the questions in the working day just after tomorrow.’
Our exploration ranges with the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
Size control of personal carbon nanotubes by nanostructuring With all the scanning tunneling microscope
Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation
Let's say, instead of working with standard major-down silicon electronics, transistors may be built from The underside up making use of one natural molecules as being the switching factors? This concept, which became The idea of now’s discipline of molecular electronics, to start with emerged inside the nineteen seventies.
There was a person problem although — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers were really not this sort of terrific conductors, which was relatively disappointing. We Consequently broadened our perspective to test to https://www.ceesdekker.net search out additional promising molecules.
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared best-down in All those days and recognized about 5 hundred genes that are minimally necessary for just a functioning cell. We wish to appear bottom-up: how can we shift from a handful of molecules to an entire Organic method?
Visualization of unstained DNA nanostructures with Superior in-emphasis transmission electron microscopy approaches
Stable-condition nanopores have demonstrated being a shockingly multipurpose probe for one-molecule Investigation of DNA. I'll describe a few of our latest findings – particularly DNA knots – in addition to our efforts to expand the abilities of good-point out nanopores even even further, while in the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.